منابع مشابه
Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.
The human lysosomal cysteine proteinases, cathepsins H, L, and B, have been mapped to chromosomes 15, 9, and 8, respectively, and the genomic structures of cathepsins L and B have been determined. We report here the chromosomal localization and partial gene structure for a recently sequenced human cysteine proteinase, cathepsin S. A 20-kilobase pair genomic clone of the human cathepsin S gene w...
متن کاملCrystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors of the innate immune system that bind peptidoglycans (PGNs) of bacterial cell walls. These molecules, which are highly conserved from insects to mammals, contribute to host defense against infections by both Gram-positive and Gram-negative bacteria. Here, we present the crystal structure of human PGRP-S at 1.70A resolu...
متن کاملCrystal Structure of Human Liver
AKR1D1 (steroid 5 -reductase) reduces all 4-3-ketosteroids to form 5 -dihydrosteroids, a first step in the clearance of steroid hormonesandanessential step in thesynthesisofallbileacids.The reduction of the carbon–carbon double bond in an , -unsaturated ketone by 5 -reductase is a unique reaction in steroid enzymology because hydride transfer from NADPH to the -face of a 4-3-ketosteroid yields ...
متن کاملCrystal structure of human fibrinogen.
A crystal structure of human fibrinogen has been determined at approximately 3.3 A resolution. The protein was purified from human blood plasma, first by a cold ethanol precipitation procedure and then by stepwise chromatography on DEAE-cellulose. A product was obtained that was homogeneous on SDS-polyacrylamide gels. Nonetheless, when individual crystals used for X-ray diffraction were examine...
متن کاملCrystal structure of human transgelin.
Transgelin (TAGLN), also known as smooth muscle protein 22 (SM22), is a highly conserved protein found in smooth muscle tissues of adult vertebrates. Abolition of transgelin gene expression by the oncogenic Ras may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development. Transgelin contains a single calponin homology (CH) domain. However,...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1998
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560070604